Researcher Information

SHIMIZU Yohei

Associate Professor

Development of novel catalyst

Department of Chemistry, Organic and Biological Chemistry

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Theme

Development of chemoselective reactions based on novel catalyst

FieldOrganometalic chemistry, Organic synthesis chemistry
KeywordChemoselective reaction, Boron catalyst, Photo catalyst, Copper catalyst
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Summary of my research

Representative Achievements

Visible Light-Induced Umpolung Alkynylation of Aldehydes
Tanaka, I.; Sawamura, M.;* Shimizu, Y.*
Org. Lett. 2022, 24, 520–524.
Visible Light Driven α-Allylation of Carboxylic Acids
Sun, K.; Ueno, M.; Imaeda, K.; Ueno, K.; Sawamura, M.;* Shimizu, Y.*
ACS Catal. 2021, 11, 9722–9728.
Boron-Catalyzed α-Amination of Carboxylic Acids
Morisawa, T.; Sawamura, M.*; Shimizu, Y.*
Org. Lett. 2019, 21, 7466–7469.
Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α-C-Allyl Carboxylic Acids
Fujita, T.; Yamamoto, T.; Morita, Y.; Chen, H.; Shimizu, Y.*; Kanai, M.*
J. Am. Chem. Soc. 2018, 140, 5899-5903.
An Expeditious Synthesis of Sialic Acid Derivatives by Copper(I)-Catalyzed Stereodivergent Propargylation of Unprotected Aldoses
Wei, X.-F.; Shimizu, Y.*; Kanai, M.*
ACS Cent. Sci. 2016, 2, 21-26.
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Related industries

Pharmaceutical, Cosmetic, Fine chemistry
Academic degreePh.D.
Academic background2006.3 BS
Department of Pharmaceutical Sciences, The University of Tokyo
2008.3 Master
Graduate School of Pharmaceutical Sciences, The University of Tokyo
2011.3 Ph.D.
Graduate School of Pharmaceutical Sciences, The University of Tokyo
2011.4-2017.12 Assistant Professor
Graduate School of Pharmaceutical Sciences, The University of Tokyo
2012.7-2012.9 Visiting Scientist
Department of Chemistry, University of Cambridge
2018.1-2020.10 Lecturer
Department of Chemistry, Faculty of Science, Hokkaido University
2019.4-2020.10 Lecturer
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
2020.11-present Associate Professor
Department of Chemistry, Faculty of Science, Hokkaido University:
Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
Affiliated academic societyThe Chemical Society of Japan, The Pharmaceutical Society of Japan, The Society of Synthetic Organic Chemistry, Japan

Department of Chemistry, Organic and Biological Chemistry

SHIMIZU Yohei

Associate Professor

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What is the research theme that you are currently focusing on?

I am working on developing novel chemical reactions that use light as an energy source. While most chemical reactions rely on heat energy, light energy can provide far greater energy levels than heat, enabling molecular transformations that were previously unimaginable. However, the highly reactive species generated by absorbing light energy are extremely challenging to handle, requiring significant ingenuity to achieve the desired molecular transformations. By harnessing the power of catalysts, I aim to precisely control these highly reactive species and create groundbreaking chemical reactions. With this goal in mind, we are dedicating ourselves to daily research and innovation.

Reaction setup using a blue LED
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What made you decide to become a researcher?

I decided to join a research lab expertizing in organic chemistry because it is a discipline where one can create something entirely new. My research theme at the time was total synthesis—a research for constructing complex molecules starting from simple ones. I became fascinated by how problems could be solved through my own ideas and trial-and-error, and how molecules gradually took shape just as I envisioned. It felt like solving a puzzle where no one knew the correct answer, and I conducted experiments every day with that sense of excitement. This experience fueled my desire to delve deeper into this world, ultimately inspiring me to pursue a career as a researcher.

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Please tell us about yourself; things you are good at, your favorites, hobbies, and daily routines.

I enjoy skiing during the winter season. Since I grew up in Nagano, I was familiar with skiing, but after starting university life, I’ve only gone skiing about once a year, if at all. Living in Sapporo, where you can ski on high-quality snow even in the nearby area, I decided to bring out my own skis again. Now that my kids are old enough to ski, going to the slopes together has become a new and exciting way to enjoy the sport.

With my kids@Asarigawa Onsen Ski Resort